Is it maybe a TdrDelay crash?
I noticed that either Win10 or the nVidia installer removes any TdrDelay setting in the registry from time to time.
I have mine set to 240 plus a TdrDdiDelay of 480 after installing the new drivers and although with my worst case Substance Painter project the UI freezes completely for about half a minute, it continues working happily afterwards.
Before that it almost instantly killed Painter.