tldr; Download Radeon Pro Driver 20.Q4 to fix Substance Painter crashing.
AMD Website Link: [https://www.amd.com/en/technologies/radeon-pro-software]
If you're like me and have struggled with Substance Painter crashing, and creating black pixel artifacts on AMD's new drivers then you're in luck!! I have found a solution that I hope works for all of you like it did for me!
Right now, the most stable driver from AMD is 20.9.2 (still has its problems), and anything above 20.11.xx is unstable. Go to AMD's website and search for Radeon Pro Drivers for Enterprise. These, I believe are drivers speciffically for content creation. I have just tested Substance Painter on it myself and can confirm all issues are solved for me. I'm unsure if these drivers will impact gaming so do at YOUR OWN RISK. (You can always revert back to other drivers)
I am running a 5700xt GPU and it seems to be the most common card with this issue on the forums.
I hope this helps everyone!