I am pretty sure the new 3ds max 2021 update has broken the substance integration, at least for vray 5 IPR. The substance2 map ignores any uvw scaling applied to the object. I tried uvw xform, uvw map and unwrap. The scaling looks fine in the viewport but now when rendering with IPR.
Substance in 3ds Max 2021, version 2.4.1
Build 19 - 657482fbccf06c47dc41a8406092ff7e448bdb31