Hi loopon,
When you import a Substance (sbsar file) in UE4, you can create several graph instances by right clicking on your "Substance Instance Factory", and selecting "Create Graph Instance".
This way, you'll have the possibility to modify some parameters of your graph to create variations.
If you only need a different uv tiling, you can use an existing Substance output, and just apply a "Texture coordinate" node to it in a new material.