John,
These are not real specific answers, but based on general reading of hardware review (analysis) sites, here are my thoughts...
RAM - "Standard" memory speeds are fine. When you try to get extra-fast memory, the cost increases a lot, but the real-world benefits range from small to miniscule. So unless you buy low-end memory, frequency-vs-timings is an interesting tehcnial research puzzle, but really doesn't matter.
CPU - That depends on the software you use. Are your favorite applications well multi-threaded or single (or dual) threaded? I'm a bit of an Intel fan, but not a rabid fanboy. I have to admit the AMD Threadripper CPUs can deliver some stunning performance at a good price. For Substance Painter and Designer, the GPU is 90% of the answer, and with a 2080Ti you'll be in great shape regardless of which of the two CPUs you select.
I will point you to my favorite hardware review site:
AnandTech.comWhat I like is they are very big on actual data, which they keep pretty much separate from their opinions. They are not just an "unboxing" review type of place. In the top banner, there is a link to "Bench" were you can pull up benchmark results for CPUs, GPUs, and more. And you can pick two products for side-by-side comparisons.