I am also having issues with painter since 2017 update altogether. I messed around with a lot of settings and applications that are running on my system and still have no idea what was causing the problem. Also one application might be a very very big problem because it has screen overlay. And it's mouse driver/utility for A4 tech mouses,
called Bloody6. Since I have not given it permission to start with windows painter is running much smoother. Even when I am playing deezer in background and have youtube open.
Here is an screenshot from nvidia control panel with the settings. Something here also might be a slowdown, have no real idea but with these settings it works for me. Also I would like to mention that I have put complete substance painter folder in trusted list on my anti-virus (360 total security).
BUT there is still a problem when starting to draw any line, sometimes, there is something like 0.1-0.3 second delay before color starts showing on a model which is not a problem when working with stamps but when I want
fine line then it really is a problem. And to make stuff worse it happens erratically with no pattern when will it happen again. So it works fine, works fine, and then starts lagging.
I've attached a log file if that could help to determine the problem. I could post the video if that would help.
And with everything said I am thinking that the google backup and sync might actually be the root of the problem. Since it gave me system wide hogs for a few times.