Hello,
I've been doing some test on skin painting and adding fine detail using only Substance Painter. For this test, I imported my zbrush alphas and painted the wrinkles (small and large), pores, stubble and eyebrows in the Substance Painter using Height.
I created several layer groups, one to control details, skin, translucency and subdermal. These maps were then exported to Toolbag 2 for rendering.
Zbrush was only used to create the base mesh with overall large details. In the 4th screen shot, you can see the base mesh exported from ZBrush that I used in Substance Painter. All detail was added using only Substance Painter from that mesh.
Cheers,
Wes