I was thinking about ways to solve this earlier today... I've grown a little obsessed with using SD4, can't get over how fast it is.
Anyway, how do you hide the seams? The alien in the above image had very noticeable wrinkles and what not on him but they weren't visible on the actual model. Was the texture created in SD4 or something else? If I have a character with a large spot (or wrinkles/stripes/etc.) on it, and it goes right over a seam, how do I line them up and hide that seam?