Hi,
Actually, the Vray renderer supports Substance since Maya 2011.5. Unfortunately, it uses an old swatch baking class that is mono-threaded due to a limitation in the Maya API. You will most probably experience some lagging issue when you'll try to wire a Substance material to a Vray shader.
However, you can use Substance Bonus Tools to create a File node shader network. This set of tools is represented by these two icons:

The first one allows you to create a Vray-ready network, and the second one to convert an existing substance network.
This way, you will be able to use substance textures with Vray, animate them or customise them during your RT session without any lag.

I hope this will help.